Long term results of PDR brachytherapy for lip cancer

Long term results of PDR brachytherapy for lip cancer

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Purpose: To evaluate the long time outcome with regard to local tumour control and side effects of a pulsed dose rate (PDR) monobrachytherapy of primary or recurrent cancer of the lip.Material and methods: Between 1995 and 2007 we treated 43 patients with primary or recurrent clinical T1-T3N0 lip cancers.There were 22 T1 patients (51%), 16 T2 (37%) and 5 T3 cases (12%).A TIES REG 7CM WIDTH median dose of 60 (55-66) Gy was given, depending on the tumour volume.The PDR treatment was delivered with 0.

83 Gy/pulse every second hour for 5.5-6.5 days.The patients were followed for a median of 55 (1-158) months.Results: The 2-, 5- and 10-year rates of actuarial local control were 97.

6%, 94.5% and 94.5%, overall survival 88.0%, 58.9% and Dryer Drum Support Bush 39.

1%, disease free survival 92.7%, 86.4% and 86.4% respectively.The regional control rate was 93%.

One patient (2%) developed distant metastases.A dosimetrical analysis showed a mean treated volume of 14.9 (3.0-56.2) cm3.

Long-term side effects were mild and the cosmetic outcome excellent, except for 1 case (2%) of soft tissue necrosis and 1 case (2%) of osteoradionecrosis.Conclusions: Local outcome is excellent and similar to other published studies of continuous low dose rate (cLDR) brachytherapy.